The peptide your skin made more of at twenty.
A prescription copper peptide cream, compounded by a licensed U.S. pharmacy and prescribed by a licensed Apex MD provider. No injections.
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GHK-Cu is a peptide of three amino acids, glycine, histidine and lysine, bound to copper. It occurs naturally in human plasma, where it was first identified in 1973.
Published reviews report that plasma levels average about 200 ng/mL at age 20 and fall to about 80 ng/mL by age 60. On cosmetic labels it appears as copper tripeptide-1.
GHK-Cu works as a signal and as a copper carrier in skin. In laboratory studies it prompts fibroblasts to make more collagen, elastin and glycosaminoglycans, and it shifts the balance of the enzymes that break down and rebuild the skin's support matrix.
A laboratory study on human skin found that it crosses the skin barrier and leaves a reservoir in the skin itself.
Every finding is labelled by the kind of study it came from, with the source linked.
In a randomized, double-blind trial of about 40 women, GHK-Cu applied twice daily for eight weeks reduced wrinkle volume by 55.8% and depth by 32.8% relative to a control serum.
Badenhorst et al., J Aging Science, 2016In a 12-week placebo-controlled study of 71 women, a GHK-Cu facial cream improved skin density and thickness and the look of fine lines. It was reported as a conference abstract.
Reported in Pickart et al., BioMed Res Int, 2015In a one-month pilot on thigh skin, collagen production rose in 70% of women using GHK-Cu, against 50% with vitamin C and 40% with retinoic acid.
Reported in Pickart & Margolina, Int J Mol Sci, 2018On excised human skin, GHK-Cu passed through the skin barrier over 48 hours and a further amount was retained in the skin.
Hostynek et al., 2010Evidence for hair growth is early and comes mostly from lab and animal work. This cream is intended for skin. Studies beyond about three months are limited.
Healthline, medically reviewedPublished research describes what was observed in a study. It is not a promise of what any product will do for you. Your provider will talk through what is realistic.
A thin layer on clean, dry skin of the face and neck, once or twice daily as your provider directs. Patch test first and wear sunscreen in the morning.
Avoid applying it at the same moment as strong vitamin C, exfoliating acids or retinoids. Use them at a different time of day or on alternate nights.
Some people notice smoother texture within a few weeks. Studies measured changes in lines and firmness at 8 to 12 weeks of consistent use.
Your provider reviews your full history. Tell them about every medication and condition, including any history of cancer.
GHK-Cu is not named on the World Anti-Doping Agency Prohibited List.
A small copper-carrying peptide your body makes naturally. Levels fall with age. Applied to the skin, it is used to support collagen and skin repair.
No. Compounded medications are not FDA-approved. It is prepared by a licensed compounding pharmacy on a provider's prescription.
Some people notice smoother texture within a few weeks. Studies measured changes in lines and firmness at 8 to 12 weeks.
Yes, in the same routine but not at the same time. Apply them at different times of day or on alternating nights.
Mostly mild redness, tingling or dryness. Stop and contact your provider if you develop a rash or swelling.
The evidence for hair is early and mostly from lab and animal work. This cream is intended for skin.
The Wolverine pairing with GHK-Cu added: a copper-carrying peptide your body makes naturally and that has been studied for skin.
Two peptides that act on separate receptors in the pituitary gland to prompt your body's own growth hormone pulse, rather than supplying the hormone directly.
BPC-157 and TB-500 together: the two most talked-about recovery peptides, prescribed as one protocol and overseen by a physician.
Answer a few questions. A licensed Apex MD provider decides whether it is right for you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Prescription products require an online evaluation with a licensed medical professional, who will determine whether a prescription is appropriate. Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness or quality. Research cited on this site describes published studies and is not a claim about what any product will do for you. Individual results vary.
